Replacement fluid is given to replace the fraction of fluid which has been produced as effluent The addition of fluid dilutes the concentration of solutes in excess in the plasma The addition of solutes in the fluid can increase the concentration of solutes that are...
There is no conclusive evidence of a benefit on survival or renal outcome with either bicarbonate or renal outcomes Both types have advantages and disadvantages: Bicarbonate Buffer May result in better control of acidaemiaMay result in improved cardiovascular...
Drug Factors Protein binding:Highly protein bound drugs (e.g. warfarin, diazepam, propranolol and phenytoin) are only cleared by RRT in small amountsMolecular weight:Larger molecules cleared less effectively by diffusive therapies Therapy Factors Timing of RRT:Drugs...
Dosing during RRT can be challenging given the numerous factors needed to be accounted for: Should not simply be dosed for reduced GFR Nomograms developed for use in stable patients on IHD can result in significant under-dosing Drug levels should be measured to aid...
