Study Intervention Population Conclusion RCT: PEITHOMeyer et alJAMA (2014)View Paper Thrombolysis (tenecteplase 30-50mg & heparin) vs. no thrombolysis (placebo & heparin) in patients with intermediate-risk/sub-massive pulmonary embolism 1006 patients across 76...
Should be considered: Where there are absolute contraindications to thrombolysis Where thrombolytic therapy has failed and the patient is critically ill Options include: Percutaneous Catheter-Directed Thrombolysis / Embolectomy Involves insertion of a catheter into...
Acute Management Parenteral, weight-adjusted anticoagulation should be used:Low-molecular weight heparin (LMWH) SCFondaparinux SCUnfractionated heparin (UFH) IVGenerally second line due to higher bleeding risk and HIT riskPreferred agent in the setting of:Overt...
Anticoagulation should be initiated without delay, while diagnostic workup in progress, in patients with: Suspected PE with haemodynamic instability Suspected PE without haemodynamic instability with a high or intermediate clinical probability ESC Guidelines...
Patients at high risk of deterioration during induction of anaesthesia, intubation, and positive-pressure ventilation: Effect of drugs on hypotensive patient Positive intrathoracic pressure reduces venous return and exacerbates RV dysfunction Intubation should be...
