How do pathogens gain entry to the cranium in meningitis?

In most cases, the infection causing meningitis arises in the nasopharynx: Can lead to intravascular invasion and bacteraemia Meningeal invasion occurs at high-level bacteraemia following penetration of the blood-brain barrier Bacteria associated with meningitis...

Case Information

On assessment the patient is tachycardic and pyrexial. He is becoming more drowsy and is now only responding to voice. He is photophobic and has a severe headache. You suspect the most likely diagnosis is bacterial...

How would you investigate this patient for suspected meningitis?

To Determine Diagnosis Consider need for CT prior to lumbar puncture:Perform to exclude mass lesion if altered consciousness, focal signs, papilledema, a recent seizure or is immunocompromisedDo not delay treatment for CT – take blood cultures and commence...