What else would make the curve move to the right?

  • A similar right shift of the curve us seen with the addition of a competitive reversible antagonist:
Description
  • The graph is a log dose-response curve with log drug dose on the x-axis and % of maximal effect on the y-axis
  • A standard sigmoid curve represents a full agonist alone
  • A second curve to the right of the first curve can be drawn to show the effect of the addition of a competitive reversible inhibitor
    • The curve sits to the right due to decreased potency of the agonist in the presence of the antagonist
    • This can be demonstrated by plotting the ED50 for both curves