• Sudden death:
    • Asymptomatic disease: 1%
    • Symptomatic disease: 50%
  • Left ventricular failure
  • Arrhythmias:
    • Ventricular arrhythmias (more common)
    • Supraventricular arrhythmias
    • Heart block
  • Infective endocarditis
  • Embolic phenomena (disintegration of the aortic valve or concomitant aortic atheroma)
  • Haemolytic anaemia
  • Von Willebrand factor deficiency and lower gastrointestinal tract bleeding due to angiodysplasia