Hyperthyroidism is a multisystem disease:

General
  • Tremor
  • Weight loss
  • Heat intolerance
  • Diaphoresis
Cardiovascular
  • Palpitations
  • Tachycardia
  • Atrial fibrillation
  • High output cardiac failure (Dyspnoea, peripheral oedema)
Respiratory
  • Tachypnoea
  • Pulmonary hypertension
Neuromuscular
  • Brisk reflexes
  • Proximal muscle weakness
Neuropsychiatric
  • Jitteriness
  • Anxiety
  • Insomnia
  • Psychosis
Gastrointestinal
  • Diarrhoea
Genitourinary
  • Infertility
  • Amenorrhoea
Cutaneous
  • Onycholysis
  • Hyperpigmentation
  • Pretibial myxoedema*
  • Thyroid acropachy*
Ophthalmic
  • Exophthalmos*
  • Periorbital oedema*
  • Eyelid lag*
Other
  • Goitre

* Pathognomonic of Grave’s Disease