Which randomised control trial demonstrated a reduction in mortality from 33% to 16% with prone position ventilation for patients with severe ARDS?

Intervention
Population
Conclusion

RCT: PROSEVA (1)

Guerin et al
NEJM (2013)

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  • Prone ventilation for 16 hours per day for up to 5 days
  • 474 patients with moderate to severe ARDS (P/F ratio <20kPa)
  • Intubated <36 hours
  • Mortality benefit demonstrated with proning (28-day mortality 16% vs. 32.8%, p<0.001)
  • No difference in ICU LOS or other complications such as pneumothorax or bronchial intubation
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