- Recently defined as:
Occurring in critically ill patients receiving propofol infusions, typically either high dose (>5 mg / kg / h ) or of long duration (>48 h), and is characterised by one or more of otherwise unexplained metabolic acidosis, rhabdomyolysis, or ECG changes, with or without AKI, hyperkalaemia, lipidaemia, cardiac failure, fever, elevated liver enzymes, or raised lactate
- PRIS was first described in the paediatric population in the 1990s
- It is a challenging diagnosis and requires a high index of suspicion