How does propofol infusion syndrome present?

  • Cardiac dysfunction (88%):
    • Acute bradycardia leading to asystole
    • Brugada-like ECG changes
    • Arrhythmias & bundle branch blocks
  • New-onset metabolic acidosis (86%):
    • Lactic acidosis & renal failure (HAGMA)
  • Renal abnormalities:
    • Renal Failure (37%)
    • Hyperkalaemia
    • Green urine – controversial whether related to PRIS
  • Rhabdomyolysis (cardiac and skeletal muscle) (45%)
  • Lipid abnormalities:
    • Hypertriglyceridemia (15%)
    • Fatty liver and hepatomegaly