Intervention
Population
Conclusion
- Early vs. Late initiation of RRT
- Early: Within 8 hours of meeting KDIGO stage 2 AKI
- Late: Within 12 hours of meeting KDIGO stage 3 AKI or emergency indication
- 231 patients with AKI and either severe sepsis or requiring catecholamine infusion
- Early group showed significantly lower mortality at 90 days (39.3% vs. 54.7%, p=0.03)
- Early vs. Late initiation of RRT
- Early: Immediately upon meeting KDIGO stage 3 AKI criteria
- Late: If oliguric 72 hours after meeting KDIGO stage 3 AKI criteria or emergency indications
- 620 patients with AKI requiring mechanical ventilation or catecholamine infusion
- No difference in mortality between early and late group (48.5% vs 49.7%, p=0.79)
- In delayed group 49% did not require RRT
- Early vs. Late initiation of RRT
- Early: within 12-hours of meeting failure by RIFLE criteria
- Late: after 48-hours of meeting failure by RIFLE criteria if no renal recovery or emergency indications
- 488 patients with severe AKI and septic shock
- No difference in mortality between early and late group (58% vs 54%, p=0.38)
- In delayed group:
- 38% did not require RRT
- 17% met indications for emergency RRT