Examples
Mechansims
Inhibition of Ionic Trapping
- Thiocyanate
- Perchlorate
- Inhibition of the sodium-iodide symporter (NIS) on the thyroid follicular cell membrane.
Inhibition of Hormone Synthesis
- Thionamides:
- Propylthiouracil
- Carbimazole
- Methimazole
- Inhibition of thyroperixodase preventing organification or iodine
Inhibition of Hormone Release
- Iodides:
- Potassium Iodide (Lugol's Iodine)
- Sodium Iodide
- Increased resistance of thyroglobulin to proteolytic degradation
- (Iodides also prevent ionic trapping and hormone synthesis)
Prevention of Peripheral Conversion to Thyroid Hormone
- Corticosteroids
- Propranolol
- Propylthiouracil
- Amiodarone
- Radiocontrast media
- Increased type 3 deiodinase activity
Destruction of Thyroid Tissue
- Radioactive iodine (131,125,123)
