- Low volume of distribution
- Low molecular weight
- Low protein binding
- Low water solubility
Memory Tip
Can be remembered by the acronym 'SMMACKK'
S econd
M etre
M ole
A mpere
C andela
K ilogram
K elvin
- Isopropyl
- Salicylates
- Theophylline
- Urea
- Methanol
- Barbiturates and anti-convulsants:
- Phenobarbital
- Carbamazepine
- Phenytoin
- Lithium
- Ethylene Glycol & other alcohols
Others include:
- Metformin
- Methotrexate
- Paraquat
- Mushroom toxins
- Antibiotics:
- Most penicillins
- Cephalosporins
- Carbapenems, aminoglycosides, metronidazole
- Some beta-blockers: sotalol, atenolol