Cytokine
Effects
TNF-α
- Fever
- Cachexia
- Depression of haematopoesis
- Hypertriglyceridaemia
- Elevated serum transaminases
- Disseminated intravascular coagulation
- Suppression of NK cell activity
TFN-γ
- Fever
- Haemophagoctytocis
- Depression of haematopoeisis
- Macrophage activation
- Stimulation of antigen presentation
- Disseminated intravascular coagulation
IL-1β
- Fever Hyperferritinaemia
- Depression of haematopoeisis
- Acute phase proteins
- T-cell activation
IL-6
- Fever
- Anaemia
- Acute phase proteins
- Renal failure
IL-10
- Suppression of T-cell activation
- Regulation of haemophagocytosis
IL-18
- Hepatic damage
- Supression of NK cell activity