- Should be diagnosed based upon clinical judgement and history in conjunction with a diagnostic score/criterion
- Scoring systems available include:
HLH Diagnostic Criteria
- Produced in 2004 by the histiocyte society
- Developed for diagnosis of primary HLH in paediatric population
- Frequently applied to adult population though poorly validated
H-score
- Weighted criteria developed in 2014
- Only validated for secondary forms of HLH in adults